The world's number one tennis player beat the domestic hope, Rafael Hodaro, in two sets – 6:2, 7:6 (0).
The Italian thus achieved his 21st consecutive victory, and his 26th in a row when it comes to the Masters.
In the first set, Janik broke his opponent's serve twice.
The second set was far more uncertain and exciting, with no breaks. A tie-break followed, and Siner was relentless – he left his rival without a point and moved on.
His next opponent will be the winner of the Artur Fis – Jiri Lehečka match.
Kasper Rud defends the title in the "Magic Box".