The world's number one tennis player and the first favorite of the tournament in the "Magic Box" was better than Briton Cameron Norrie in two sets - 6:2, 7:5 after less than 90 minutes of play.
This is the Italian's 20th consecutive victory.
In the first set, Nori took a 1:0 lead, and then Janik won five consecutive games and easily won this part of the game.
The second set was far more uncertain. Siner broke for 3:2, but Nori responded with a rebreak to make it 3:3. After that, both held serve, and at 5:5, Janik made a crucial break and then confirmed his place in the second quarterfinal in Madrid.
He will seek his first semi-final in the Spanish capital against the winner of Vit Kopriva – Rafael Hodar.