The military said on social media that "certain terrorist organizations" were targeted in the strikes, when three people were killed in the first ship, two in the second and three people in the third ship. The military did not provide evidence of the alleged drug smuggling but released a video showing one ship before it exploded.
President of the USA Donald Tramp justified these attacks to stop the supply of drugs and that it was an "armed conflict" with drug cartels.
The Trump administration is facing increasing scrutiny from members of the US Congress over a campaign of ship strikes that have killed at least 95 people in 25 known actions since early September. Included in that analysis was the subsequent attack on the ship in which the two survivors of the first attack were killed.
The latest attacks on ships are taking place ahead of a briefing by US security officials organized for all members of Congress on the military campaign of President Trump's administration.
Defense Secretary Pete Hegsett, Secretary of State Marco Rubio and other senior national security officials are expected to brief members of the US House of Representatives and Senate.
Campaign to strike ships believed to be smuggling drugs ramped up to pressure Venezuela's president Nikolasa Madura who is accused of narco-terrorism in the US.
In a major escalation last Sunday, US forces seized a tanker that the Trump administration accused of smuggling illegal oil. Maduro says the real reason for the US military operations is to oust him from power.
The US military has increased its presence in the region and launched a series of deadly strikes on alleged drug-trafficking vessels in the Caribbean Sea and eastern Pacific. Trump says ground attacks will follow soon, but did not provide details on the location.