The City Ground was silenced by Gue Sung with a goal in the 80th minute.
Lyon drew 1-1 away to Celta.
The home team took the lead with a goal from Rueda in the 25th minute, but then in the 55th minute they were left with ten men when Broja Iglesias was sent off.
Three minutes before the end, the final score was set by Real's loanee Endrik.
Kanicovski and Jozef gave Ferencvaros a two-goal lead ahead of the rematch with Braga.
Genk narrowly defeated Freiburg at home. The decisive goal came from El Ouhadi in the 24th minute.
The second leg is in seven days.
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