Medvedev had only three winners and 27 unforced errors in just 12 games played. He did not have a single game point and missed two break points, both in the opening game of the match.
The Russian has stated several times that he does not like playing on clay, but that certainly cannot be an excuse for such a debacle.
Interestingly, the Italian, who is currently only 90th on the ATP list, reached the round of 16 without losing a game, because at the start, while leading 4:0, his rival Roberto Bautista Agut retired due to injury.
His next opponent will be the talented Brazilian Joao Fonseca, who eliminated Frenchman Arthur Rinderknech in three sets.
The third favorite of the tournament, Alexander Zverev, advanced thanks to an unreal turnaround against the 109th ranked tennis player in the world, Christian Garin.
The German won in three sets – 4:6, 6:4,7:5 after almost three hours of great battle.
Garin led 4:0 in the deciding set and served, but Zverev returned a break point to reduce it to 5:2, and then tied five games in a row and used the third match point to advance to the top 16.
Zverev will play Belgian Zizou Bergs in the quarterfinals, who surprised 13th seed Andrei Rublev 2-0 (6-4, 6-1).
The title in the Principality is being defended by Carlos Alcaraz, who is also the top seed in the tournament.